TDP-43 (TAR DNA-binding protein 43) is a protein that plays a critical role in regulating gene expression and RNA metabolism in cells. Research in this area focuses on understanding the functions of TDP-43, its involvement in neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and potential therapeutic strategies targeting TDP-43 dysfunction. Studies have shown that abnormalities in TDP-43, such as its mislocalization or aggregation, contribute to the pathogenesis of neurodegenerative diseases. Researchers are investigating the molecular mechanisms underlying TDP-43-related diseases and developing novel treatments to target TDP-43 pathology. Overall, research in the TDP-43 field aims to elucidate the role of this protein in disease and pave the way for the development of effective therapies.